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How Tirzepatide Works Tirzepatide activates both GIP and GLP-1 receptors, with a stronger emphasis on GIP receptor activation

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While generally well tolerated, GLP-1RAs have been associated with gastrointestinal side effects, including rare reports of bowel obstruction

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In addition, activating GLP-1R reduced Iba-1, IL-1 and TNF- release and inhibited TNC microglial number and morphological changes (process retraction) following nitroglycerin administration