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This context of high prevalence, progressive natural history, and multisystemic impact underscores the urgent need for effective, broadly applicable pharmacotherapies

In particular, the burden of CVD will intensify, given that people with diabetes experience a two- to fourfold increased risk of developing ASCVD compared to those without [6] and that CVD accounts for two-thirds of deaths in the overweight/obese population [7]

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Liver disease may be one of the next major frontiers, with growing evidence that incretin-based therapies can improve MASH resolution and fibrosis-related endpoints

Wall Street is enthusiastic about Zepbound in part because it may cause more weight loss than Wegovy