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A trial of 88 people with obesity and pre-diabetes showed that taking a GLP-1 improved insulin sensitivity even before significant weight loss had occurred

According to the UK SmPC, Ozempic is typically initiated at 0.25 mg weekly for four weeks, then increased to 0.5 mg weekly, with potential further escalation to 1 mg weekly and then 2 mg weekly if needed for additional glycaemic control and if tolerated

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These comparisons mix a single agent versus a combination, which makes riskbenefit decisions more complex and should be handled by a clinician

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