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AT1R expression in mesangial cells and podocytes, induced by high glucose levels, promotes intracellular expression of profibrotic and pro-inflammatory mediators, such as transforming-growth factor beta (TGF- ), vascular endothelial growth factor (VGEF), and interleukin-6 (IL-6) leading to hyperplasia and hypertrophy, mainly of the proximal tubule, together with extracellular matrix production (34)

The pharmaceutical manufacturers of the GLP-1s have coupon programs and Patient Assistance Programs that can offset the cost of your co-pay

Sustainable Results - At Victory Medical Institute, we believe in empowering patients to maintain their health beyond structured treatments

They play a very important role in psoriasis patients with type 2 diabetes, and the administration of a GLP-1 analogue improved the psoriasis severity by decreasing the dermal T-cell number and IL-17 expression (41)

The story of GLP-1 fits perfectly within this

The honest framing is that they are not interchangeable, and the decision should be based on the patients full clinical picture rather than the headline number alone