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The combined central and peripheral effects produce a much larger and more durable energy-balance shift than earlier GLP-1 agonists could achieve

Of the total number of subjects in the integrated dataset consisting of EPIC-HR and EPIC-SR who were randomized to and received PAXLOVID (N=1,578), 165 (10%) were 65 years of age and older and 39 (2%) were 75 years of age and older

References accessed 08 December 2025 accessed 08 Nov 2025 Han Wu, Wenjia Yang, Tong Guo, Xiaoling Cai and Linong Ji, Trajectory of the body weight after drug discontinuation in the treatment of antiobesity medications, BMC medicine, 2025

This can make maintaining weight loss more challenging over time

16, 2021 (American Heart Association News) -- For more than three
