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doi: 10.7759/cureus.33509

its existence has been controversial and it is thought that these cells act as progenitors, constantly renewing the gustatory epithelium during the synthesis phase of TBC renewal, nonetheless, there are many questions regarding its cycling, especially in rodents ( The shared receptor families (T1Rs and T2Rs) illustrate a common evolutionary template for chemosensory signaling between the oral cavity and the gastrointestinal tract

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Increased paracellular permeability, following disruption of the intestinal tight junctions enables bacteria to leak out of the intestinal lumen into the blood stream ( Bile Acid Metabolism Bile acids are synthesized in hepatocytes via cytochrome P450-mediated oxidation of cholesterol and then secreted into the intestinal lumen through the biliary system