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-cell apoptosis is mediated by a series of cascade mechanisms of the cysteine protease family, and current studies on hyperglycemia-induced -cell apoptosis have focused on the balance between the pro-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) and the anti-apoptotic Bcl family (Bcl-2 and Bcl-xl) (Tomita, 2016), and apoptosis occurs only when the concentration of the pro-apoptotic protein Bcl-2 on the mitochondrial membrane of the intrinsic pathway exceeds the concentration of the anti-apoptotic protein

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C.BouhnikY.et al (2014)

Kidney stones are typically caused by a buildup of minerals like calcium oxalate or uric acid in the urine

As estrogen declines during perimenopause and menopause, insulin sensitivity can decrease

When sexual side effects typically start and when they usually resolve Timing matters enormously when interpreting sexual side effects on semaglutide