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[1] [3] Additionally, Ozempic slows gastric emptying, which helps to moderate post-prandial glucose spikes and promotes satiety, often leading to weight lossa beneficial effect for many patients with type 2 diabetes

The first-line recommendation is lifestyle and dietary change

Weve done the very best job we can in our clinical trial population in ensuring safety, and weve looked at every outlier in terms of liver enzyme elevations

Broader immune-mediated reactions may develop weeks later or after dose escalation

Nutritional patterns like the low carbohydrate diet and ketogenic diet can target reduction of de novo lipogenesis and increase fatty acid oxidation that will eventually help insulin resistance downstream [62,67,70,88,89]

This process produces short chain fatty acids that bind free fatty acid receptors, which in turn secrete GLP-1