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Watanabe JH, Kwon J, Nan B, et al

The synergistic combination of these three receptor agonisms distinguishes retatrutide from single-pathway (GLP-1 only) or dual-pathway (GLP-1/GIP) agonists, making it a unique and powerful tool for metabolic research

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injections of 100 nmol kg 1 PYY analogue ( n = 7 mice and n = 6 cages), 100 nmol kg 1 PYYMK-801 ( n = 7 mice and n = 4 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 7 mice and n = 5 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 6 days

Retatrutide Phase 2 Obesity Trial Investigators

Using the same spot repeatedly can cause lipohypertrophy (hardened areas under the skin) that impair absorption