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A National Institutes of Health (NIH)-funded study has found that an emerging class of GLP-1 weight loss drugs suppress eating for pleasure, or hedonic feeding, in mice by modulating a reward circuit deep within the brain

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GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) act on the brain as well as the gut, and a 2026 real-world cohort study from Kamel-Abusalha et a