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Significant effects of HM11260C (efpeglenatide) on body weight over 20 weeks in obese subjects without diabetes: a randomised, double-blind, placebo controlled study [abstract]

doi: 10.1038/s41574-022-00783-3 106 KnopFKUrvaSRettigantiMBensonCTRoellWCMatherKJet al

Orlistat is the active ingredient in two brand-name drugs for weight loss: Xenical is a prescription-only 120 mg pill that you take three times a day with each meal containing fat (during or up to one hour after the meal)

However, the total drug exposure (measured as AUC) remains the same

Major pharmaceutical companies, including Novo Nordisk, Sanofi, Eli Lily, Janssen and Merck are currently developing their own GLP-1/glucagon co-agonist candidates, most of which are in Phase 1 or Phase 2 clinical trials [225]