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The metabolic and neurotransmitter support that B6 provides, while not dramatic, creates a slightly smoother experience during what is already a challenging physiological transition

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The cost of replacing a questionable pen is minimal compared to the risks of inadequate glycemic control or potential adverse effects from degraded medication

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Discussion In this mechanistic analysis of the SUMMIT trial, we found that, compared with placebo, treatment with the long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist tirzepatide reduced BP and estimates of circulatory volume expansion in patients with obesity-related HFpEF

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