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Constipation While less common than nausea or diarrhea, some users report constipation

[15] This signal has not been confirmed in humans, but it is reflected in the prescribing information for approved GLP-1-based medicines such as semaglutide (see the UK Summary of Product Characteristics for Wegovy, available via the electronic Medicines Compendium)

People lose weight, but they also feel tired

Genetic variations in GLP-1 receptor genes (GLP1R rs6923761), GIPR genes (rs1800437), and appetite-control genes (FTO rs9939609, MC4R rs17782313) influence how effectively semaglutide works for each person

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