stafford semaglutide & tirzepatide We are excited to announce that GLP-1 medications are back! Weekly injections or monthly med pickup 😃 If you've been waiting to resume your treatment or are interested in getting started, now Semaglutide vs Tirzepatide: Which GLP-1

Description

This type of hair shedding is often associated with a condition known as telogen effluvium, which can be triggered by physiological stressors such as significant weight loss or metabolic changes

Tirzepatide, also known by its brand name Monjaro, is another GLP-1 agonist that works similarly to Semaglutide

Results vary based on genetics, adherence, diet quality, and exercisewhich is why PlexusDx offers the Precision Peptide Genetic Test to identify your individual response potential and optimize your treatment from the start

Caution should also be used when combining phentermine with diabetes medications, which can include semaglutide drugs like Ozempic or Rybelsus

Common Side Effects (Both Drugs) Most Frequent (especially during first 4-8 weeks): Nausea (most common, affects 15-30% of patients) Vomiting (5-15% of patients) Diarrhoea (15-25% of patients) Constipation (10-20% of patients) Abdominal pain (8-15% of patients) Decreased appetite (expected effect) Fatigue or dizziness (5-10% of patients) Comparative Tolerability Mounjaro Considerations: Slightly higher rates of early GI intolerance (particularly at higher doses) Prescribing information includes warnings about severe gastrointestinal disease 12-15% discontinuation rate due to GI side effects in clinical trials Side effects increase with higher doses (10mg, 12.5mg, 15mg) Requires gradual dose escalation to minimise discomfort Ozempic Profile: Generally well-tolerated with gradual dose titration Lower discontinuation rates in some comparative studies More extensive long-term safety data (approved since 2017) Better patient compliance due to lower GI side effect burden Serious Risks (Both Medications) FDA and DCGI Warnings: Possible pancreatitis (inflammation of pancreas) Gallbladder disease (cholecystitis, cholelithiasis) Thyroid C-cell tumours (theoretical concern from animal studies) Gastroparesis (delayed gastric emptying rare but serious) Kidney problems (acute kidney injury in severe dehydration cases) Diabetic retinopathy (worsening of diabetic eye disease) Low blood sugar (hypoglycaemia, especially with insulin/sulfonylureas) Contraindications: Personal or family history of medullary thyroid carcinoma (MTC) Personal history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to semaglutide or tirzepatide Severe gastroparesis or gastrointestinal disease Tips to Minimise Side Effects Start low, go slow Always begin with the lowest dose Eat smaller, more frequent meals Avoid large, fatty meals Stay hydrated Drink 2-3 litres of water daily Take with food Can help reduce nausea (though not required) Avoid trigger foods Greasy, spicy, or very rich foods Gradual dose escalation Dont rush to higher doses Communicate with your doctor Report persistent or severe side effects Treatment Protocols and Administration Ozempic Dosing Schedule Standard Titration: Weeks 1-4: 0.25mg once weekly (starter dose) Weeks 5-8: 0.5mg once weekly Week 9+: Increase to 1mg once weekly if additional glycaemic control needed Maximum dose: 2mg once weekly (if 1mg insufficient) Administration: Subcutaneous injection (tummy, thigh, or upper arm) Can be taken any day of the week, same day each week Can be taken with or without meals Rotate injection sites to prevent lipodystrophy Step-by-step guide on using injection pens Mounjaro Dosing Schedule Standard Titration: Weeks 1-4: 2.5mg once weekly (starter dose) Weeks 5-8: Increase to 5mg once weekly Weeks 9-12: Increase to 7.5mg once weekly (if needed) Weeks 13-16: Increase to 10mg once weekly (if needed) Weeks 17+: Can increase to 12.5mg or 15mg for maximum effect Administration: Subcutaneous injection Once-weekly dosing, same day each week More dosing flexibility for personalised treatment Requires careful click counting for accurate dosing Mounjaro KwikPen click counting guide Who Should Choose Which Drug