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To determine whether the combination therapy of SGLT2is and DPP4is has a synergistic efficacy in slowing the progression of DKD, we performed chronic administration with a SGLT2i, EMPA or the combination of EMPA and a DPP4i, LINA into Spontaneously Diabetic Torii (SDT)-fatty rats, leptin receptor-mutated rats, that were given containing 0.5% NaCl (DKD rats)