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Retatrutide (LY3437943): This Lilly molecule is a triple agonist targeting the glucose-dependent insulinotropic polypeptide (GIP), GLP-1, and glucagon receptors (so called Triple G)

The result is improved insulin sensitivity, steadier energy, better sleep, and a quieter inflammatory baseline without the trade-offs of full clinical doses

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Semaglutide was also associated with a 4.5- to 6.4-kg weight loss

Discovery remains centered on clinical trial data, post-marketing adverse event reports, internal safety analyses, and communications related to gastrointestinal risks

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