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Saxenda, are approved for use in New Zealand as adjunctive treatments for weight loss (not funded)

[27] demonstrated that GIP receptor neurons differ in their connectivity, transcriptomic profile, peripheral accessibility, and appetite-controlling mechanisms with vast heterogeneity of the central GIP receptor signalling axis and further studies are needed to clarify the effects of GIP pharmacology on feeding behavior

doi: 10.1046/j.1471-4159.2003.01812.x 138 PerryTGreigNH

No embryotoxicity or teratogenicity was seen in animals that received orlistat at doses much higher than the recommended human dose

Data from already published studies is presented in this review