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Results of the first phase 3 trial comparing orforglipron with oral semaglutide found that patients with diabetes lost on average 6-8% of their body weight with orforglipron, compared with 4-5% on semaglutide

With a 10-second ECG or a 24-hour monitor, you might still be left wondering if something was missed

But when Brooks lost her job in late 2024, she also lost her benefits and couldn't afford the medication

Patients with a history of alcohol use disorder should also abstain, as even small amounts may trigger relapse, and the metabolic complications of resumed heavy drinking would be particularly detrimental in the context of diabetes or obesity management

Acosta A, Camilleri M, Burton D, ONeill J, Eckert D, Carlson P et al

Decisions about any peptide belong with a qualified clinician, and neither compound is offered here for human therapeutic use