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doi: 10.1152/ajpendo.00076.2022

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Starting too aggressively can increase the likelihood of side effects, while increasing too slowly may delay results for patients who need stronger metabolic support

Amgen, Lilly HRS-9531 ( GLP-1 GIP) Jiangsu Hengrui.

Taken together, this series of studies suggests that the relative modest increase of endogenous GLP-1 activity via DPP-4Is may be insufficient to reach a therapeutic threshold