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Its not going to trigger nausea as much, Stanford says

49 It has been shown that inhibitors of phosphodiesterase type 4 can elevate cAMP intracellular levels, and can downregulate the release of pro-inflammatory cytokines in the mucosa of IBD patients

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However, average masks the true range: approximately 35% of trial participants lost more than 25% of body weight, while 15% lost less than 15%

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We are losing around 20% of muscle mass, but that is not different from diets that restrict calorie intake