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IELs protect the epithelial barrier by promoting pathogen clearance and lysing pathogen-infected cells (Yusta et al., 2015)

Chronic hyperglycemia has been shown to lead to lymphatic dysfunction, and insulin resistance may be a risk factor for developing lymphedema (Doruk Analan and Kaya, 2022

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AF often develops as part of the natural ageing process of the heart, but several conditions can contribute: High blood pressure (hypertension) Heart valve disease or structural abnormalities Coronary artery disease Thyroid imbalance Sleep apnoea Excess alcohol, caffeine, or stimulant use Obesity and metabolic syndrome Lifestyle factors particularly high blood pressure, weight, and alcohol intake play a significant role in both the development and progression of AF

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Findings from observational data are at higher risk of bias and have less trustworthy results that are inconsistent across different study designs and subgroup analyses