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When to speak to your GP Contact your GP, nephrologist, or prescriber if you experience: Reduced urine output or dark-coloured urine, which could suggest dehydration Persistent nausea or vomiting that prevents you from keeping fluids down Swelling in your ankles, legs, or around your eyes (could indicate worsening fluid retention) Significant or rapid changes in blood pressure Muscle cramps, weakness, or irregular heartbeat (possible signs of electrolyte imbalance) Unexplained fatigue thats worse than your usual CKD-related tiredness Blood in your urine Feelings of anxiety, low mood, or being overwhelmed by managing your condition If youre unable to keep any fluids down for more than 24 hours, seek urgent medical advice

-Mark R

However, for some people, these side effects can feel challenging

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As an example, we have looked for reported hypoglycemia in patients treated with different antidiabetes drug classes

For long-term success, those on GLP-1 should cultivate healthy habits leading to lasting behavioral changes