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Safety and Efficacy of the New, Oral, Small-Molecule, GLP-1 Receptor Agonists Orforglipron and Danuglipron for the Treatment of Type 2 Diabetes and Obesity: Systematic Review and Meta-Analysis of Randomized Controlled Trials

EZGLP1T-36K

77 A meta-analysis of 76 RCTs, involving over 100,000 adults with overweight, obesity, or type 2 diabetes found that GLP-1 RA treatment, compared to placebo or other active comparators, was associated with a modestly elevated risk of cholelithiasis (RR: 1.27, 95% CI 1.10, 1.47), cholecystitis (RR: 1.36, 95% CI 1.14, 1.62), and overall biliary disease (RR: 1.55, 95% CI 1.08, 2.22), corresponding to an absolute increase of approximately 27 events per 10,000 patients per year

These medications can reduce your thirst signals, so you may not feel thirsty even when your body needs fluids

Compounding allows for tailored doses or alternative delivery methods, offering personalized solutions for patients who might not respond well to commercially available options