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The pancreas and liver were collected for biochemical, gene expression, and histological analyses, and the results demonstrated that the leaf extracts of Gymnema sylvestre increased plasma insulin levels and significantly reduced blood glucose by modulating the expression of key genes involved in glucose metabolism and diabetes control, such as Irs1, Irs2, SREBP1c, Foxo1, Ins-1, Ins-2, and NF-B [84]

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