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However, along with the rapid titration schedule came gastrointestinal side effects, especially nausea and vomiting, which were the most common reason for discontinuation

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Compared with exenatide, lixisenatide is generally well tolerated, with a lower incidence of hypoglycemia, lower immune response at the injection site, and less side effects such as nausea and vomiting

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December 2, 2025: Australia Regulators Add Risk of Suicidal, Self-Harm Thoughts to Trulicity Label Patients who took Trulicity have reported experiencing thoughts of harming themselves or ending their lives, the Therapeutic Goods Administration warns