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78-LB: Efficacy and Safety of Tirzepatide, a Dual GIP/GLP-1 Receptor Agonist, Compared With Insulin Degludec in Patients With Type 2 Diabetes (SURPASS-3)

This dual action produces more weight loss than GLP-1 alone

They're expressed on immune cells, including mast cells

Systemic exposure (AUC) of the active metabolites, 4-trans-hydroxyglyburide (M1), and 3-cis-hydroxyglyburide (M2), was reduced by 13% and 15%, and Cmax was reduced by 18% and 25%, respectively

Conclusion Storing peptides correctly is essential for preserving their structural integrity and bioactivity

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