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Infection prevention is critical, as cellulitis occurs frequently in lymphedematous limbs and accelerates disease progression

10.2337/dc14-0514 92

Adherence to dosing schedules and gradual dose titration can minimize adverse effects

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You cannot change most of these elements, such as age, genetics, and chronic medical problems

Having reviewed the literature extensively, I believe Metformin will remain relevant even as newer medications gain popularity
