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Do not use tirzepatide if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

David Smith, urologist and co-founder of medical device company BladGo Medical, told Drugwatch

Taking semaglutide and tirzepatide together can result in severe side effects

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(Statistics found in a 2022 study)

Consequently, GLP-1 RAs were developed with molecular modifications that prolong their activity in vivo , enabling the development of once-weekly injectable preparations