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However, as polypeptide drugs, GLP-1RAs are easily hydrolyzed by enzymes in the gastrointestinal environment

Keywords: Glucagon, Glucagon-like peptide-1 receptor agonist, Glucose-dependent insulinotropic peptide receptor, Incretin, Obesity, Type 2 diabetes mellitus Introduction Type 2 diabetes mellitus (T2DM) and obesity are becoming more and more common worldwide, a phenomenon which greatly increases morbidity and mortality from conditions like cancer and heart disease, among many others [1]

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68 Furthermore, the potential association between GLP-1 RA use and more serious GI complications such as acute pancreatitis, cholelithiasis, and bowel obstruction remains controversial due to inconsistent findings in observational studies and meta-analyses

DWAT is a layer of adipocytes with metabolic activity, immune cells, fibroblasts and ADSCs in the dermis