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GLP-1, a hormone secreted by the intestines, lowers blood glucose and promotes weight loss through multiple mechanisms: it enhances insulin secretion in a glucose concentration-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces food intake via central appetite suppression

Among the non-insulinoma PanNETs, immunohistochemical insulin or proinsulin positive cases were categorized as Inspos, and both negative cases as Insneg

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