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Description
They are not powered to detect rare adverse events or to evaluate long-term safety outcomes

2014;99(4):E729-33

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Side Effects and Safety: What the Data Shows The side effect profile is broadly similar to Wegovy and Mounjaro but with some unique additions due to the glucagon mechanism

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Clinical trials consistently show tirzepatide produces about 5% more body weight loss than semaglutide, likely due to this dual mechanism
