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Combination therapy is not recommended both medications should not be taken together as it can be unsafe and may increase gastrointestinal side effects

Grunvald E, et al

We could expect from early treatment with oral semaglutide and other GLP-1 analogues a better control of cardiovascular risks as a result of its actions exerted before atherosclerosis develops, in addition to the benefits of superior glucose control and weight loss

Introduction Glucagon like peptide-1 (GLP-1) is a 30 or 31 amino acid long peptide hormone mainly secreted by 3 tissues in the human body: enteroendocrine L cells in the distal intestine, alpha cells in the pancreas, and the central nervous system (1)

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Diabetes Obes Metab 2015;17:179-87
