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The Tirzepatide groups consistently showed shorter mean follow-up periods (390.09395.18 days), which corresponds to its more recent market introduction compared to the other medications studied (Supplementary Table 1)

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Yet, like any twist in the treatment script, Rybelsus comes with its own set of side effects, including occasional nausea which might be a surprise to patients used to their regimen

As of April 2026, tirzepatide is FDA-approved only as a weekly injection (Mounjaro for type 2 diabetes, Zepbound for weight management)
