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This effect is likely mediated by synergistic interactions between the endogenous cannabinoid system and the endogenous opioid system at both the spinal cord and central nervous system levels [66]

Albumin and IgG can be taken up by endothelial cells lining blood vessels by fluid-phase pinocytosis and enter the endosomal pathway

Pharmacol Res 2021

HbA1c was reduced, and the mean weight loss was 5.6% of baseline

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But manageable
