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3.2.2 How microbiota influence MS The altered gut microbiome observed in MS has fueled intense research interest in elucidating the factors that shape this microbial community and the mechanisms through which these microbes may influence MS pathogenesis

Characterization of the glucagonlike peptide1 receptor in male mouse brain using a novel antibody and in situ hybridization

These incretin effects explain the initially surprising weight loss observed in the treatment groups of the cardiovascular trials, with subjects taking GLP-1/GIP agonists losing from 3% to 12% of their body weight

Methods 3.1

INTERNATIONAL ROUNDUP (PharmaTimes, March 9-14) Regulatory Approvals: MHRA approved deuruxolitinib for severe alopecia areata NHS to offer fezolinetant for menopause hot flushes Clinical Trials: Aplagon dosed first patient in phase 2a peripheral arterial disease trial UCB reported bimekizumab superiority in psoriatic arthritis Kainova reported positive phase 1 data for DT-9081 in advanced solid tumours EnteroBiotix completed enrolment for EBX-102-02 trial in microbiome therapy Industry Appointments: Dr Michelle Morrow appointed CSO at Nucleome Dr Klaas Zuideveld named CEO at TECregen Rebecca Simmons appointed COO at Qureight KEY DATA POINTS SUMMARY Metric Value GLP-1 sales (MAT Feb 2026) 1,446 crore (177%) Stranded containers 40,000-45,000 Export cargo affected $1-1.5 billion War surcharge per container $3,000-5,000 Glycerin price increase 64% (Dec-Mar) Paracetamol API increase 26% (Dec-Mar) Polypropylene price increase 55/kg (since Dec) Universal NutriScience valuation 3,000 crore API exports (FY25) 41,500 crore API imports (FY25) 39,215 crore ABOUT THE INDIAN PHARMACEUTICAL INDUSTRY India is the "pharmacy of the world," supplying over 60% of global vaccine demand and 40% of generic medicines in the US

Uptake of the various liposomes by the transfected BMECs was analyzed by fluorescence imaging and flow cytometry