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The triple-receptor mechanism stood out because it targets appetite, insulin, and energy expenditure all at the same time, not just one pathway

On the other hand, long-acting GLP-1 RAs have only a modest effect on gastric emptying, possibly caused by tachyphylaxis due to continuous activation of the GLP-1 receptor [115, 116]

Overall, the total number of studies and patients is limited, especially when regarding the heterogeneity of IBD pathologies

doi:10.3389/fphar.2025.1613610 13

The 0.5 ml capacity is perfect for peptide dosing ranges of 0.2 to 0.5 ml