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The salivary glands of gila monsters produce a GLP-1 peptide that does not have a DPP-4-recognized site leading to the first therapeutic incretin, exenatide - a twice daily subcutaneous injection [25]

To date, more than a dozen GLP-1 drugs have been launched globally

High out-of-pocket costs, complex cost-sharing structures, and gaps in prescription drug coverage are major healthcare policy barriers to medication use in underserved and older patient populations

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Medicare beneficiaries will have a $50 monthly copay for the newly covered obesity indications, which will presumably apply towards the Part D $2,100 (in 2026) annual out-of-pocket maximum