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**Letrozole**, on the other hand, suppresses aromatase activity, temporarily lowering estrogen while preserving receptor function

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You'll start on a low dose so your body has time to adjust, and the dose increases gradually over the first 16 weeks. The standard schedule is 0.25mg once a week for the first four weeks, then 0.5mg, then 1mg, then 1.7mg, and finally 2.4mg as your ongoing maintenance dose from week 17 onwards. Each step lasts around four weeks. Your clinician may slow this down if you're struggling with side effects, or keep you on a lower dose if it's working well for you

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The study found that the drug stimulates insulin secretion, suppresses appetite and increases satisfaction to promote weight loss.