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Novo is essentially trying to innovate past its own product before the generics get there upgrade the semaglutide franchise into something new enough that a generic of the old thing becomes less relevant
The results of the AWARD-11 trial concur that weight loss occurs most frequently in patients with the highest starting BMI on the highest doses of Trulicity

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doi: 10.1038/s41586-021-03775-x 121 LalliM
