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In SOUL, composite HF endpoints were analysed as a secondary outcome, with oral semaglutide resulting in a non-significant reduction in HF events

Additionally, these agents have been shown to decrease epicardial fat deposits, reduce cardiomyocyte apoptosis, optimize cardiac energetics, and enhance myocardial glucose oxidation [53, 54]

Moving from peptide-based biologics to small molecules like orforglipron redefines scalability, simplifies supply chains, and expands global reach

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These findings suggest that gastrointestinal distension serves as a physiological stimulus for GLP-1 secretion and that this mechanism may be effective in preventing and ameliorating hyperphagic obesity

GLP-1 Receptor Agonists vs