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Semaglutide treatment resulted in a 24% reduction in major kidney disease, a composite of kidney failure, at least a 50% reduction in estimated glomerular filtration rate from baseline or death from kidney-associated or cardiovascular causes

Depending on the medicine, injections may be taken once daily or once weekly

In 2020, it was the 129th most commonly prescribed drug in the United States, with more than 4 million prescriptions filled

This approval marked an important milestone as the first GLP-1 receptor agonist to reduce the risk of worsening kidney disease, kidney failure, and death due to cardiovascular disease in these patient populations

These results further support the idea that Akkermansia supplementation is able to mitigate IR, prediabetes, and improve body composition

A separate prespecified SELECT analysis confirmed that semaglutide reduced cardiovascular events irrespective of baseline HbA1c or change in HbA1c, including in normoglycemic patients and in patients who showed no glycemic improvement whatsoever