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The combination therapy produced substantially greater weight loss than either agent alone

38 Grauslund et al identified all patients with diabetes in Denmarks national health registry and found that semaglutide was an independent predictor of incident NAION (HR = 2.19)

Most GLP-1s are given as shots

Either way, though, there are some people who cannot use this option because of interactions with other medications or health conditions

To minimise unwanted effects and maximise metabolic actions, a covalent conjugate of oestrogen and GLP-1 was developed

Metabolic Health: Improves overall metabolic markers including insulin sensitivity and lipid profiles