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Biomed Res Int 2020:2947549 Jetten AM (2009) Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism

As estrogen acts to increase production of prostacyclin, it is possible that the effect of hormone replacement therapy on the heart is counteracted by these NSAIDs
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She recommends exploring plant-based proteins to mitigate this risk

doi:10.1016/j.bbr.2019.112359 84
