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These findings suggest that differences in factors that regulate meal patterns as well as metabolic adaptations may contribute to the different responsiveness to these drugs

doi: 10.1016/j.biomaterials.2021.120944 122 GaspariTLiuHWelungodaIHuYWiddopREKnudsenLBet al

These findings matter because fatty liver disease (both alcoholic and non-alcoholic forms) drives progressive fibrosis and cirrhosis risk in untreated cases

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Phentermine can also cause seizures, so taking them together increases the risk, especially for anyone who has a preexisting seizure disorder