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States may choose to start participating in BALANCE starting on a date of their choosing between May 1, 2026, and January 1, 2027

doi: 10.1056/NEJMoa2401755

Schedule regular provider check-ins Monthly check-ins during the first few months allow for symptom review, dose refinement, and lab monitoring when needed

1 These products feature portion-controlled options, such as grain bowls, mini flatbread pizzas with cauliflower crust, and high-protein sandwich melts designed to support the nutritional needs of individuals consuming smaller portions due to medication-induced appetite suppression

more frequent at higher concentrations Diarrhea common during early exposure or escalation periods Constipation reported alongside other GI disturbances Increased heart rate average increase of roughly 2 to 3 beats per minute Administration site reactions ranging from mild redness to localized nodules Gallbladder disorders including gallstones, especially at higher concentrations and longer durations Acute kidney injury primarily linked to volume contraction from GI fluid loss Pancreatitis a labeled risk, though large meta-analyses show no significant increase vs

Patients receiving semaglutide (0.5 or 1.0 mg) for 104 weeks demonstrated a significantly higher risk of diabetic retinopathy complications, including vitreous hemorrhage, blindness, or required procedural treatment compared to those receiving placebo (HR, 1.76