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This approach could theoretically prevent Cas9 DNA integration into the host genome, thereby reducing the risk of unintended off-target effects and further enhancing the safety of LNP-based in vivo genome editing

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A higher incidence of nausea (12-24%), diarrhoea (15-17%), decreased appetite (6-12%), and vomiting (6-10%) was reported in participants treated with tirzepatide than in those treated with insulin degludec (2%, 4%, 1%, and 1%, respectively)

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