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Methodological quality was assessed using AMSTAR 2

What the Latest Clinical Trial Results Show According to publicly reported late-stage trial data: Participants receiving higher doses achieved average weight loss approaching 2530% over approximately 68 weeks Some individuals lost more than 70 pounds during the study period Participants with obesity and knee osteoarthritis also reported significant reductions in joint pain These outcomes exceeded the average weight loss typically reported in clinical trials of currently approved GLP-1 medications

Dorsomedial hypothalamic NPY and energy balance control

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These findings were consistent with the network metaanalysis estimates, which are presented in Figure 3B, and Supplement 7.2

"Bupropion (Wellbutrin)." NAMI, accessed on October 5, 2023, MedlinePlus