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Additionally, GLP-1 signalling in the prefrontal cortex may hypothetically enhance cognitive control and decision-making processes, potentially helping individuals resist urges to drink, though this mechanism is primarily supported by animal models rather than human data

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The main pharmacodynamic difference between the two classes is that the short-acting agonists lower postprandial glucose by delaying gastric emptying, while the long-acting GLP-1RAs have a stronger incretin effect [1,23,24]

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Mounjaro delivered superior and consistent A1C reductions against all of the comparators throughout the SURPASS program, which was designed to assess Mounjaro's efficacy and safety in a broad range of adults with type 2 diabetes who could be treated in clinical practice, Juan Pablo Fras, MD, medical director of the National Research Institute and a researcher involved in the SURPASS program, said in a statement