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In addition to SGLT2 inhibitors and GLP-1 receptor agonists, finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has demonstrated significant cardiovascular and kidney-protective effects in people with type 2 diabetes mellitus and CKD or HF [129-132]

Priority design elements: (i) Statistical Power and Follow-up

10.1038/nrendo.2012.140 [DOI] [PubMed] [Google Scholar] 19.Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, et al

Wharton, S., Davies, M., Dicker, D., Lingvay, I., Mosenzon, O., Rubino, D

For tech transfer, it meant adapting the semaglutide synthesis (the same peptide active) to a continuous chemical synthesis process, and validating an oral dose-uniformity assay that was different from the injectable

Starting treatment as soon as possible with FDA-approved medications and potentially changing to retatrutide when it becomes available is a practical approach