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DISCUSSION In this study, 7.5 mg of tirzepatide did not produce significant improvements in glycemic control or body weight after switching from 1.0 mg of semaglutide, while the 10 mg dose resulted in significant HbA1c reduction, but not significant weight loss

According to NICE guidance, the target HbA1c for most adults with type 2 diabetes is 48 mmol/mol (6.5%), though individualised targets may be higher based on factors such as age, duration of diabetes, and risk of hypoglycaemia

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GLP-1 Weight Loss in Frederick, MD: How These Medications Work & Whats New in 2026 GLP-1 medications like Semaglutide and Tirzepatide are reshaping weight loss